Spraguedawley and wistar rats are both established models of sucroseinduced ir and hypertg pagliassotti et al. Read online sprague dawley rat taconic biosciences book pdf free download link book now. Spraguedawley sd and long evans strains are available for transgenic rat production. The rats are maintained as an outbred closed colony. Palm puree is rich in antioxidants and is produced via blending various proportions of mesocarp fibre and crude palm oil. Dawley rats were randomly divided into three groups n10, including the control, oa and oa with treadmill exercise oae groups. The sprague dawley outbred model was developed by sprague dawley, inc. During the acclimation and experimental periods, the rats were housed in polycarbonate cages maximum of 3 rats per cage in a room with controlled temperature. Genetic characterization of outbred sprague dawley rats.
Reference values for young normal spraguedawley rats. Also, huff 2002 reported that the positive ri findings for toluene were less than overwhelming, the negative ntp findings for vinylidene chloride less than adequate because the use of a maximum tolerated dose mtd had not been clearly demonstrated, and the positive ri findings for vinylidene chloride were for increases in leukemias and total malignant tumors in sprague. The current study aims to investigate the influence of five rare earth elements rees i. To produce experimental model of diabetes, 42 male spraguedawley rats were administrated with a modified high fat high sucrose diet hfhsd.
Animals from low, mid and high dose groups received leaf extract at 250, 500 and mgkgday, respectively. It is the most widely used rat model for biomedical research. Streptobacillus moniliformis, streptococcus f3 haemolitica, bordetella. Evaluating the oestrogenic activities of aqueous root.
Inhibition of testosteroneinduced hyperplasia of the. I am a model organism used by duke university to research the impacts of chemical exposure on behavior, memory, and cognitive ability. Sexspecific reference intervals of hematologic and. Rift valley fever virus induces fetal demise in sprague. Lewis, fischer 344, and spraguedawley rats display. The second was a threegeneration dietary assay conducted over the dose range 1. Hypoglycemic activity of cucumis sativus extract on. Rift valley fever virus rvfv infections in pregnant livestock cause high rates of fetal demise. Sprague dawley rat article about sprague dawley rat by.
The aim of this study was to assess the acute and subchronic toxicity of palm puree in male and female sprague dawley rats. Spraguedawley rats rattus norvegicus specific pathogen free for. Biopersistence of silver nanoparticles in tissues from. Evaluation of the chronic toxicity and carcinogenicity of. History of the sprague dawley rat erikacarlys weblog. Cdsdbr that were on randomly selected toxicity studies at the huntingdon research centre between 1981 and 1984 at time points of 8, 17, 30, 56, and 108 weeks. The results of two independent spraguedawley sd rat multigeneration assays of bisphenol a bpa have recently been reported. Mixed reflux caused more gross mucosal injury than acid reflux. Sprague dawley rats obtained from different sources. To address how rvfv infection during pregnancy causes detrimental effects on the fetus, we developed a pregnant rodent model of rvfv infection. Sprague dawley rats were first bred by the sprague dawley farm in madison, wisconsin in 1925 through multiple crosses with a singlehooded male and six albino female rats.
The present report describes a rare case of spontaneous hemangiosarcoma in a nineweekold male spraguedawley rat. A number of rat species are used in research, contract research organizations and in the pharmaceutical industry including the wistar, sprague dawley and fischer 344. Tumors in spraguedawley rats and swiss mice table 2 location of 219 spontaneous tumors occurring in 165 60 males and 105 females of 360 spraguedawley rats observed for 540 days site and tumor male female skin and s. Carcinogenicity studies in spraguedawley sd rats show that pfoa induces the tumor triad pattern liver adenomas, leydig cell tumors, and pancreatic acinar cell tumors similar to several peroxisome proliferatoractivated receptor alpha ppar. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle to ovalshaped cells that showed invasive growth without encapsulation and were. Pdf comparative analysis of growth characteristics of sprague. Almost all laboratory and domestic pet rats belong to a single species, the norway rat rattus norvegicus. Figure 4 summarizes the detection of intracellular production of ros in spraguedawley rats exposed to agnps and controls. Effect on sperm production in adult spraguedawley rats. The first was a twogeneration assay conducted using the oral route over the dose range 0. Sprague dawley rats were slightly, more sensitive than the wistar strain for effects on bp and nephron endowment.
Sprague dawley rat an overview sciencedirect topics. Spraguedawley rat synonyms, spraguedawley rat pronunciation, spraguedawley rat translation, english dictionary definition of spraguedawley rat. Nih received stock from sprague dawley, inc in 1945. They had free access to altrominr pellet diet except in starvation experiments and to tap. Spraguedawley rat definition of spraguedawley rat by. The list of acronyms and abbreviations related to sds spraguedawley rats. In 1991, 8 colonies were selected to form the igs foundation colony. Sprague dawley rat taconic biosciences pdf book manual. Materials and methods data for the morphologic studies were obtained from 500 male and 500 female control spraguedawley rats crl. Fat intake affects adiposity, comorbidity factors, and. Background hematologic and biochemical analytes of spraguedawley rats are commonly used to determine effects that were induced by treatment and to evaluate organ dysfunction in toxicological safety assessments, but reference intervals have not been well established for these analytes. The 90day toxicology feeding experiment was conducted in spraguedawley rats fed with diets containing 70% of either trs rice flour, its nearisogenic rice flour or the control diet. Fourweekold male and female, specificpathogen free spf sprague dawley rats were purchased from orient bio korea and acclimated for 7 days before starting the experiments. Altered health outcomes in adult offspring of sprague.
Reproductive and teratogenic effects of lidocaine in spraguedawley rats you will receive an email whenever this article is corrected, updated, or cited in the literature. Request pdf metabolic differences between sprague dawley and wistar han male rats while sprague dawley sd rats are often used for nonclinical safety testing, wistar han wh rats are also. Pdf acute oral toxicity effects of momordica charantia. Mccomb dj, kovacs k, beri j, zak f 1984 pituitary adenoma in old spraguedawley rats. Established in 1925 by robert dawley, the original sprague dawley rat colony was obtained by harlan in 1980 through the acquisition of spraguedawley, inc.
The rats were housed in individually ventilated temperature and humidity controlled cages strain and agematched two per cage with hardwood chip bedding. Male spraguedawley rats 90120g body weight bred and maintained at the biomedical research unit, university of kwazulunatal was used in this study. The study was conducted according to oecd guideline 407. The common domestic rat, which is found worldwide and is a destructive pest of crops and stored food and a carrier of disease. Agerelated changes in thyroid structure and function in. Established in 1925 by robert dawley, the original sprague dawley rat colony was obtained by harlan in 1980 through the acquisition of sprague dawley, inc. Sprague dawley sd rat has a wide array of historical research use including in the field of cardiology.
The incidence and increased severity of the disease occurs more frequently in the aging male rat than in female rats, and in certain lab species namely f344 and spraguedawley rats and to a much lesser degree in wister and long evans hooded rats. The weights of the rats were recorded weekly, and the influence of testosterone and pumpkin seed. Pdf download for reference values for young normal spraguedawley rats. Pdf genetic background in animal models is an intrinsic research. Taconic received stock from the nih animal genetic resource in 1970. Longterm health effects occured with undernutrition during either window examined in this study, but the uni021 period resulted in lower birth weight and more severe effects later in life. Esophagitis in spraguedawley rats is mediated by free. Metabolic differences between sprague dawley and wistar.
The objective of this study was to evaluate the toxic characteristics of rauvolfia tetraphylla leaf extract in sprague dawley rats after treatment for minimum 7 days by oral route. Like other rat breeds used in research, the sprague dawley makes for a good general model for the study of human toxicology, reproduction, pharmacology, and behavioral research. Sprague dawley rat synonyms, sprague dawley rat pronunciation, sprague dawley rat translation, english dictionary definition of sprague dawley rat. Ijerph free fulltext the accumulation and metabolism. Comparative analysis of growth characteristics of sprague dawley. Reference intervals as presently defined for these analytes in spraguedawley rats. The animals had free access to standard rat chow meadows feeds, pietermaritzburg, south africa and water, with a 12hour light12hhour dark cycle. About sprague dawley rats lauren and heathers blog. Illumina truseq pcrfree library prep kit and quality checked using an. We will breed up to 3 founders to wildtype rats of matching strain background and genotype their offspring to obtain f1 rats bearing the transgene. The administration of agnps to rats significantly enhanced the ros level at four tested doses as compared to the control animals. We selected 100 specific pathogen free spf female spraguedawley rats, 34 weeks old and weight 7090g, and all the animals were provided by the laboratory animal center of army medical university no. Spraguedawley rat article about spraguedawley rat by.
Reproductive and teratogenic effects of lidocaine in. However, you may choose to have us breed the founders further to obtain f1 rats. All books are in clear copy here, and all files are secure so dont worry about it. You can manage this and all other alerts in my account. The rats were refreshed with nih genetic resource stock in 1998. Studies on the antidiabetic activities of cordyceps. The experimental procedure was approved by the laboratory animal center at army medical university, chongqing. Sprague dawley rat definition of sprague dawley rat by. The sprague dawley breed of rat, like those used in the current psychology 381 class, is used widely throughout medical and psychological research. The influence of reflux on esophageal glutathione levels was also examined. The sd rats from charles river laboratories crl and harlan.
Defined flora spraguedawley rodents are relatively shortlived at approximately 2 years. Spontaneous tumors in spraguedawley rats and swiss mice1. Free radicalmediated esophagitis was studied during duodenogastroesophageal reflux mixed reflux or acid reflux in rats. Spraguedawley and wistar rats are both established models of. Dawley from a hybrid hooded male and a female wistar rat. Charles river provides laboratory animal models, including the sprague dawley rat, for use in basic research and nonclinical drug discovery and. This study shows that physicochemical and sensory attributes of pasteurized buffalo milk fortified with ferrous sulfate 0. Sprague dawley rat synonyms, sprague dawley rat antonyms. This site is like a library, you could find million book here by using search box in the header.
Simultaneous oral administration of either pumpkin seed oil 2. The rat is the most commonly used rodent species for toxicology studies. Splenic hemangiosarcoma in a young spraguedawley rat. Taconic offers the sprague dawley outbred rat at the standard murine pathogen free health status which is appropriate for most studies. For the acute toxicity study, animals administered single palmpuree doses 2000 mg kg. The rats average about 5 grams of food per day per 100 grams of body weight and about 1012 milliliters of water per 100 grams of body weight. Spontaneous neoplastic lesions in aged spraguedawley rats. Outbred sprague dawley rats are among the most commonly used rats for neuroscience.