Reactions of the blood coagulation cascade are propagated by complex enzymes containing a vitamin kdependent serine protease. Apr 05, 2016 the clotting cascade is definitely much more complex than what has been simplified for the purposes of this post, and it is very interesting how the human body works. Martin phillips, ron baker, eduardo munoz, hamood rehman, carol gibson, christine mayernik. A diagram pdf is provided of the testing coagulation cascade that shows the factors that make up both the intrinsic and extrinsic pathways. Coagulation is the final and most definitive process of hemostasis and allows for the creation of a highly stable, longlived clot. Add upload a file basic cascade training cascade cms. Unfortunately, things become more complicated when the upper reaches of the cascade are explored. Coagulation cascade extrinsic pathway begins when trauma to vasculature exposes tissue factor to blood activating coagulation factor vii fvii active fvii complex initiates and amplifies the coagulation cascade coagulation cascade intrinsic pathway activates factor xii upon surface damage resulting in downstream. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. A recombinant form of human factor viia eptacog alfa activated, novoseven has u. Coag cascade wksht key coagulation cascade worksheet 1. Coagulation cascade powerpoint templates designed by skilled, experienced and professional graphic designers that are intended to solve the big issue of time consumption. To accomplish this the coagulation cascade is composed of a set of components that interact with each other, both in sequence and with a few feedback loops, to. View and share this diagram and more in your device or register via your computer to use this template.
The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. The thrombin kicks fibrinogen into action and factor xiiia ties things up. Leak detection study dtph5611d000001 final 03391201 kiefner and associates, inc. Coagulation of blood, coagulation disorders, coagulation cascade, coagulation factors coagulation koagyo. The coagulation cascade is the secondary defensive response to blood vessel damage, the primary being the immediate movement of platelets to the site of injury and their aggregation to form a temporary plug. University of chicago med student who demonstrates an easy memory mechanism for.
Easy coagulation cascade part 1 of 2 youtube tutorial. Blood contact with the polyvinyl chloride tubing utilized in the extracorporeal circuit, the squeezing mechanism of the roller head pump, and various applications of blood. Describe the specimen type used for coagulation studies 2. Xii, perkallikrien, high molecular weight kiniogen. The clotting cascade explained hopefully in a manner that is easy to understand and remember. Visceral involvement, including hepatopathy and renal tubulopathy, may. Increased pt, ptt, bleeding time, and ddimers, with decreased platelet. View test prep coag cascade wksht key from cls 4300 at devry university, chicago. Blood clotting is the transformation of liquid blood into a semisolid gel.
Commenting tool bar should be displayed automatically. There is a pdf and print button within the sharing buttons at the end of the post, between the tumbler and email icons. The coagulation cascade is now recognized to be a series of proteolytic events mainly localized to the surface of activated platelets. The casein in milk is coagulated curdled by the addition of acetic acid or citric acid.
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. Each of these complexes is built around an enzyme component. Results mean prothrombin time results increased from 11. Tissue factor is the only membrane bound member of the coagulation cascade. However, many disease states that may lead to bleeding are more common in this.
The coagulation cascade is the mechanism by which blood clots, and is important to understand. If necessary, make changes to the core statement to better reflect your understanding of the text. Coagulation cascade testing intrinsic and extrinsic pathways presence of platelet phospholipid needed to test intrinsic pathway partial thromboplastin time platelet phospholipid substitute chloroform extract from rabbit brain thromboplastin reflects clotting ability of intrinsic andcommon pathway. The cascade model was developed by macfarlane in 1964 of nature followed by the waterfall model by davie and ratnoff in science. The first factor in the sequence activates the second factor, which activates the third factors and so on. Autosomal recessive mitochondrial complex iii deficiency is a severe multisystem disorder with onset at birth of lactic acidosis, hypotonia, hypoglycemia, failure to thrive, encephalopathy, and delayed psychomotor development. Heme coagulation cascade mcmaster pa student resource. Here are 2 animated illustrations of the coagulation pathway, which might help make things easier. The entire process of coagulation is directed toward creating fibrin, a highly fibrous protein that essentially forms a mesh, entrapping blood cells and platelets, creating an unyielding gellike substance that can prevent blood loss from large tears in the.
Coagulation cascade pathway, intrinsic pathway, extrinsic pathway. Affordable and search from millions of royalty free images, photos and vectors. Coagulation article about coagulation by the free dictionary. Artefact due to sample collection or contamination, e. The original cascade or waterfall models of coagulation proposed 2 independent pathways by which coagulation could be initiated in a plateletfree environment. Understanding the coagulation cascade is one of the most difficult areas that medical students and doctors face in the field of hematology. In veins, vessel wall disruption is a less important trigger of coagulation, although vessel wall injury can occur in the setting of surgery or with indwelling central venous catheters. Bilddateien in pdf oder wenn sie zusatzliche einstellungen benotigen, konnen sie einen pdf. Blue boxes and arrows include various hemostatic agents with their mechanism of actions. At one time the physiological cascade and the testing cascade were thought to be the same.
Review of physiology and clinical applications figure 3 coagulation simplified this figure presents a coherent schematic of the coagulation cascade, in order to simplify all the factors with roman numerals and highlight 3 activation complexes. The process of tissue factor initiated blood coagulation is discussed. Aug 03, 20 coagulation cascade powerpoint templates designed by skilled, experienced and professional graphic designers that are intended to solve the big issue of time consumption. Activation of coagulation cascade get microthrombi and consumption of platelets, fibrin, and coagulation factors may have increased or decreased tendency to bleed. Pdf stands for the portable document format, used to display documents in an electronic form independent of the software, hardware or operating system they.
This figure presents a coherent schematic of the coagulation cascade, in order to simplify all the factors with roman numerals and highlight 3 activation complexes. Once you have the core principles in place, it is much easier to build on in terms of all the positive versus negative feedback loops and other circulating proteinsmolecules. Termination phase understanding the coagulation cascade. Leak detection study dtph5611d000001 final 123112 to. Agerelated changes to the coagulation system do not lead to a higher risk of bleeding, but in fact favour the development of thrombosis. Jan 22, 2014 the cascade model was developed by macfarlane in 1964 of nature followed by the waterfall model by davie and ratnoff in science. Assessment and management of coagulopathies in the elderly. Department of transportation pipeline and hazardous materials safety administration december 10, 2012 by dr.
Assessment and management of coagulopathies in the elderly introduction bleeding is a common clinical problem in the elderly. Wenn sie jedoch andere dateien konvertieren mochten, z. Coagulation cascade editable flowchart template on creately. Mcgrawhill displays a short animation, while johns hopkins university shows a more detailed one. Tissue factor tf, previously known as factor iii of the extrinsic pathway is the primary initiator of coagulation in both normal and disease states. These are fully editable slides and organized in a way to simplify the most complex topics and present it in an attractive manner.
All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. When you open the pdf file using adobe reader, the. Both suggested that coagulation was divided into two pathways. The activation of clotting factors occurs in a sequential manner. It outlines the basis of hemostasis and disorders of this cascade can lead to hypercoagulability or conversely, problems with clotting, leading to hemorrhage. Design criteria for decentralized testing products v. An example of this is the initiation of cardiopulmonary bypass. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Leak detection study dtph5611d000001 final 123112 to phmsa. The coagulation cascade is initiated when blood becomes traumatized by exposure to a foreign surface. This series of reactions is called the clotting cascade.
Use pdf export for high quality prints and svg export for large sharp images or embed your diagrams anywhere with the creately viewer. Viewing pdfs and viewing preferences, adobe acrobat. When blood comes in contact with a negatively charged surface like glass or a phospholipid membrane, fxii hegeman factor is activated where kininogen. Nov 16, 2007 coagulation cascade animated understanding the coagulation cascade is one of the most difficult areas that medical students and doctors face in the field of hematology. Blood clotting is the transformation of liquid blood into. More common triggers are reduced blood flow stasis, altered properties of the blood that render it more prone to clotting thrombophilia, andor alterations. At the same time, the secondary response is underway, which results in the production of fibrin strands that strengthen the platelet plug. The coagulation cascade could seemingly be triggered by two pathways, the intrinsic contact activation and the extrinsic tissue factor. The special pro cess flow for converting existing pdf files to pdfa is explained in detail later on. If you want to commit it to memory, i suggest printing the simple flow chart and keeping it in an area that you visualise often.